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Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 147-156 doi: 10.1007/s11684-010-0030-9

Abstract: The pandemic H1N1 2009 influenza virus has caused the first influenza pandemic of the 21st century, leading

Keywords： influenza A virus     H1N1 subtype     pandemic     pathogenesis     virulence factors     immunity     management     antiviral    

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Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract: antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1)Constructs carrying different HA1 regions were delivered into eukaryotic cells by SalmonellaSpecifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producingCD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomeof influenza viruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2and the 2013 novel H7N7, H7N9 and H10N8 subtypes, thereby threatening both the poultry industry and

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with littlemajority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1Here we review what is known about the human humoral immune response to vaccination and infection with H7subtype influenza viruses on a polyclonal and monoclonal level.to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses.

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 103-111 doi: 10.1007/s11705-021-2064-8

Abstract: was developed based on boron-dipyrromethene (BODIPY) with high sensitivity for the detection of UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration.this perfect biocompatibility and cell permeability, BDMP was successfully used to image endogenous UGT1A8In addition, BDMP could also be used to visualize UGT1A8 in tumor tissues.These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated

Keywords： UDP-glucuronosyltransferase 1A8     fluorescent probe     subtype selectivity     fluorescence imaging    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.quinone oxidoreductase 1 to diagnose tumours.quinone oxidoreductase 1-activating drug β-lapachone.quinone oxidoreductase 1.

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1522-y

Abstract:

• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.

Keywords： Methanogens     Biological Nitrogen Removal (BNR)     Simultaneous     Methammox     C:N ratio    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H)refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers.Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 97-104 doi: 10.1007/s11705-019-1828-x

Abstract: Bis-alkylsulfonic acid and polyethylene glycol (PEG)-substituted BF azadipyrromethenes have been synthesized by an adaptable and versatile route. Only four synthetic stages were required to produce the penultimate fluorophore compounds, containing either two alcohol or two terminal alkyne substituents. The final synthetic step introduced either sulfonic acid or polyethylene glycol groups to impart aqueous solubility. Sulfonic acid groups were introduced by reaction of the bis-alcohol-substituted fluorophore with sulfur trioxide, and a double Cu(I)-catalyzed cycloaddition reaction between the bis-alkyne fluorophore and methoxypolyethylene glycol azide yielded a neutral bis-pegylated derivative. Both fluorophores exhibited excellent near-infrared (NIR) photophysical properties in methanol and aqueous solutions. Live cell microscopy imaging revealed efficient uptake and intracellular labelling of cells for both fluorophores. Their simple synthesis, with potential for last-step structural modifications, makes the present NIR-active azadipyrromethene derivatives potentially useful as NIR fluorescence imaging probes for live cells.

Keywords： NIR-fluorophores     live cell imaging     NIR-AZA    

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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1AThe effect is better seen as an overall change in the total HepG2 N-glycome, primarily due toWe propose an alternative way to evaluate the N-glycome composition via estimating the overall

Keywords： interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 396-399 doi: 10.1007/s11684-008-0076-0

Abstract: hour after oral glucose tolerance test (OGTT-1h HG).Seven years of follow-up visits were performed on 189 elderly male outpatients with OGTT-1h HG and dataFollow-up visits revealed that 19 patients with OGTT-1h HG were diagnosed with diabetes (10.1%), 78 patientsSynchronized comparison with IGT patients showed that the ratio of OGTT-1h HG patients turning to diabeteswas lower than that of IGT patients (21.1%, = 13.05, < 0.01), and the ratio of OGTT-1h HG patients

Keywords： special attention     prevalence     unchanged     dyslipidemia     elderly    

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N

Hao Wang, Zhi-yuan Wang, Ben-dong Wang, Zhong-he Jin, John L. Crassidis,roger@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 2,   Pages 141-286 doi: 10.1631/FITEE.1900358

Abstract: s are widely used in attitude-determination and control systems of satellites. The main deficiency of static s is the requirement of a small field of view (FOV). A typical FOV for a static is about 20° to 30°, which may not be sufficient for low-Earth-orbiting s. A novel compact with an FOV of nearly 180° is developed here. The Earth sensor comprises a panoramic annular lens (PAL) and an off-the-shelf camera with an uncooled complementary-metal-oxide-semiconductor (CMOS) infrared sensor. PAL is used to augment FOV so as to obtain a complete infrared image of the Earth from low-Earth-orbit. An algorithm is developed to compensate for the distortion caused by PAL and to calculate the vector of the Earth. The new is compact with low power consumption and high precision. Simulated images and on-orbit infrared images obtained via the ZDPS-2 are used to assess the performance of the new . Experiments show that the accuracy of the Earth sensor is about 0.032°.

Keywords： Infrared Earth sensor     Micro-satellite     Attitude determination system    

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Nonlinear dynamic analysis for elastic robotic arms

H. KORAYEM, H. N. RAHIMI

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 2,   Pages 219-228 doi: 10.1007/s11465-011-0218-y

Abstract:

The aim of the paper is to analyze the nonlinear dynamics of robotic arms with elastic links and joints. The main contribution of the paper is the comparative assessment of assumed modes and finite element methods as more convenient approaches for computing the nonlinear dynamic of robotic systems. Numerical simulations comprising both methods are carried out and results are discussed. Hence, advantages and disadvantages of each method are illustrated. Then, adding the joint flexibility to the system is dealt with and the obtained model is demonstrated. Finally, a brief description of the optimal motion generation is presented and the simulation is carried out to investigate the role of robot dynamic modeling in the control of robots.

Keywords： robotic arms     elastic link     elastic joint     nonlinear dynamics     optimal control    

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Title Author Date Type Operation

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Journal Article

Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Journal Article

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Journal Article

N

Hao Wang, Zhi-yuan Wang, Ben-dong Wang, Zhong-he Jin, John L. Crassidis,roger@zju.edu.cn

Journal Article

Nonlinear dynamic analysis for elastic robotic arms

H. KORAYEM, H. N. RAHIMI

Journal Article